Associate Research Scientist

The Gallitto Lab is seeking a highly motivated ARS to join our translational pediatric neuro-oncology program. Our research focuses on identifying novel targeted therapies and radiosensitizers for diffuse midline glioma (DMG) and leveraging advanced drug-delivery platforms-including focused ultrasound (FUS) and convection-enhanced delivery (CED)-to overcome the blood-brain barrier. Our projects integrate mechanistic DNA damage/repair biology, single-cell sequencing, high-throughput drug screening, and orthotopic mouse modeling.

• Lead in vitro mechanistic studies (DNA damage/repair assays, Western blotting, CRISPR perturbations, histopathology, FACS).
• Perform in vivo DMG mouse work, including stereotactic brainstem implantation, CED pump placement, RT on our Small Animal Radiation Research Platform (SARRP), PK studies, and survival analyses.
• Execute drug screening and combination therapy studies with drugs/compounds in the context of radiation both in vitro and in vivo
• Analyze and interpret data, contribute to manuscripts and grants, and help advance projects toward clinical translation.

• PhD or MD/PhD in cancer biology, neuroscience, molecular biology, radiation biology, or related field.
• Strong experience in mammalian cell culture and mouse handling/survival surgery.
• Background in DDR/PARP biology, cancer neuroscience, and radiation biology preferred
• Experience with intracranial tumor models, CED/FUS, or LC/MS pharmacokinetics is a major plus.
• Excellent organizational skills and ability to drive independent projects.

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.